| | Player |
POS
| IP | W | L | ERA | WHIP | K | BB |
| 1 |
Jack Flaherty
| SP | 159 | 10 | 10 | 4.07 | 1.21 | 176 | 50 |
| |
| 2 |
Framber Valdez
| SP | 185 | 12 | 9 | 3.67 | 1.24 | 168 | 64 |
| 3 |
Tarik Skubal
| SP | 188 | 14 | 8 | 2.81 | 0.96 | 228 | 39 |
| 4 |
Casey Mize
IL-15
| SP | 146 | 9 | 9 | 4.25 | 1.23 | 121 | 39 |
| 6 |
Justin Verlander
IL-15
| SP | 131 | 7 | 9 | 4.71 | 1.29 | 106 | 47 |