| | Player |
POS
| IP | W | L | ERA | WHIP | K | BB |
| 1 |
Kevin Gausman
| SP | 180 | 12 | 10 | 3.88 | 1.22 | 180 | 52 |
| |
| 2 |
Shane Bieber
| SP | 76 | 5 | 3 | 3.64 | 1.19 | 74 | 19 |
| 3 |
Eric Lauer
| SP | 7 | 1 | 1 | 4.81 | 1.42 | 7 | 3 |
| 4 |
Chris Bassitt
| SP | 172 | 11 | 11 | 4.10 | 1.29 | 158 | 59 |
| 5 |
Max Scherzer
| SP | 103 | 7 | 6 | 3.87 | 1.13 | 105 | 27 |
| 6 |
Jose Berrios
| SP | 185 | 12 | 11 | 4.21 | 1.24 | 158 | 52 |
| 7 |
Easton Lucas
| SP | 14 | 1 | 1 | 4.53 | 1.38 | 13 | 6 |
| 8 |
Bowden Francis
IL-60
| SP | 141 | 10 | 8 | 4.14 | 1.16 | 130 | 37 |
| 9 |
Alek Manoah
IL-60
| SP | 21 | 1 | 1 | 4.24 | 1.29 | 20 | 8 |